Rx-Cre, a tool for inactivation of gene expression in the developing retina

Genesis. 2006 Aug;44(8):361-3. doi: 10.1002/dvg.20225.


Rx is a homeobox-containing gene that is critical for vertebrate eye development. Its expression domain delineates a field of cells from which the retina and the ventral hypothalamus develop. The 5' upstream regulatory sequences of the medaka fish Rx gene are functionally conserved during evolution to a degree that they direct gene expression into the Rx-expressing field of cells in mice. Using these sequences, we made a Cre line that can be used for inactivation of gene expression in the developing retina.

Publication types

  • Letter
  • Research Support, N.I.H., Extramural

MeSH terms

  • Alleles
  • Animals
  • Eye Proteins / genetics*
  • Eye Proteins / physiology*
  • Gene Expression Regulation, Developmental*
  • Genes, Homeobox*
  • Genes, Reporter
  • Green Fluorescent Proteins / metabolism
  • Homeodomain Proteins / genetics*
  • Homeodomain Proteins / physiology*
  • Integrases / genetics
  • Lac Operon
  • Mice
  • Mice, Transgenic
  • Oryzias / embryology
  • Oryzias / genetics
  • Retina / embryology*


  • Eye Proteins
  • Homeodomain Proteins
  • Rx protein, mouse
  • Green Fluorescent Proteins
  • Cre recombinase
  • Integrases