Pax: A Murine Multigene Family of Paired Box-Containing Genes

Genomics. 1991 Oct;11(2):424-34. doi: 10.1016/0888-7543(91)90151-4.

Abstract

A murine multigene family has been identified that shares a conserved sequence motif, the paired box, with developmental control and tissue-specific genes of Drosophila. To date five murine paired box-containing genes (Pax genes) have been described and one, Pax-1, has been associated with the developmental mutant phenotype undulated. Here we describe the paired boxes of three novel Pax genes, Pax-4, Pax-5, and Pax-6. Comparison of the eight murine paired domains of the mouse, the five Drosophila paired domains, and the three human paired domains shows that they fall into six distinct classes: class I comprises Pox meso, Pax-1, and HuP48; class II paired, gooseberry-proximal, gooseberry-distal, Pax-3, Pax-7, HuP1, and HuP2; class III Pax-2, Pax-5, and Pax-8; class IV Pax-4; class V Pox neuro; and class VI Pax-6. Pax-1 and the human gene HuP48 have identical paired domains, as do Pax-3 and HuP2 as well as Pax-7 and HuP1, and are likely to represent homologous genes in mouse and man. Identical intron-exon structure and extensive sequence homology of their paired boxes suggest that several Pax genes represent paralogs. The chromosomal location of all novel Pax genes and of Pax-3 and Pax-7 has been determined and reveals that they are not clustered.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Chromosome Mapping
  • Cloning, Molecular
  • Crosses, Genetic
  • DNA Probes
  • Drosophila / genetics
  • Genes, Regulator / genetics*
  • Haplotypes
  • Mice / genetics
  • Molecular Sequence Data
  • Multigene Family / genetics
  • Polymorphism, Restriction Fragment Length
  • Reading Frames
  • Sequence Alignment

Substances

  • DNA Probes

Associated data

  • GENBANK/S75394
  • GENBANK/S75396
  • GENBANK/S75398
  • GENBANK/S75400
  • GENBANK/S75402
  • GENBANK/S75404
  • GENBANK/S75473
  • GENBANK/S76455
  • GENBANK/S76456
  • GENBANK/S76457