Deregulated NF-kappaB activity in haematological malignancies

Biochem Pharmacol. 2006 Oct 30;72(9):1069-80. doi: 10.1016/j.bcp.2006.06.011. Epub 2006 Jul 18.

Abstract

The NF-kappaB family of transcription factors plays key roles in the control of cell proliferation and apoptosis. Constitutive NF-kappaB activation is a common feature for most haematological malignancies and is therefore believed to be a crucial event for enhanced proliferation and survival of these malignant cells. In this review, we will describe the molecular mechanisms underlying NF-kappaB deregulation in haematological malignancies and will highlight what is still unclear in this field, 20 years after the discovery of this transcription factor.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Apoptosis / physiology*
  • Cell Proliferation*
  • Gene Expression Regulation / physiology
  • Hematologic Neoplasms / metabolism*
  • Hematologic Neoplasms / pathology
  • Humans
  • NF-kappa B / metabolism*
  • NF-kappa B / physiology

Substances

  • NF-kappa B