A single centre, open-label, cross-over study of pharmacokinetics comparing topical zinc/clindamycin gel (Zindaclin) and topical clindamycin lotion (Dalacin T) in subjects with mild to moderate acne

J Dermatolog Treat. 2006;17(3):154-7. doi: 10.1080/09546630600727115.


Zinc/clindamycin gel (Zindaclin 1%) gel, is a new once-daily topical acne treatment (Strakan Ltd) containing clindamycin phosphate equivalent to 1% clindamycin and zinc acetate in a formulation, which leads to a reduced systemic absorption of clindamycin through the skin. The objective of the study was to compare the systemic absorption of clindamycin from zinc/clindamycin gel and clindamycin lotion (Dalacin T topical lotion, Pharmacia Ltd) after repeated twice-daily topical administration for two periods of 5 days with an intervening gap of 2 weeks in 24 subjects with mild to moderate acne. Plasma Cmax, and AUC0-12 of clindamycin measured after single and multiple applications of zinc/clindamycin gel were between 30% and 50% lower than for clindamycin lotion. As zinc/clindamycin gel is a topical treatment for acne, the lower systemic bioavailability may be beneficial because there may be a correspondingly lower risk of systemic events in zinc/clindamycin gel-treated subjects.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Acne Vulgaris / blood
  • Acne Vulgaris / drug therapy*
  • Acne Vulgaris / pathology
  • Administration, Cutaneous
  • Adolescent
  • Adult
  • Anti-Bacterial Agents / administration & dosage
  • Anti-Bacterial Agents / pharmacokinetics*
  • Anti-Bacterial Agents / therapeutic use
  • Area Under Curve
  • Clindamycin / administration & dosage
  • Clindamycin / pharmacokinetics*
  • Clindamycin / therapeutic use*
  • Cross-Over Studies
  • Drug Combinations
  • Female
  • Humans
  • Male
  • Severity of Illness Index
  • Skin Absorption
  • Treatment Outcome
  • Zinc Acetate / administration & dosage
  • Zinc Acetate / pharmacokinetics*
  • Zinc Acetate / therapeutic use


  • Anti-Bacterial Agents
  • Drug Combinations
  • Clindamycin
  • Zinc Acetate