Role of coagulation factor XIII (FXIII) in angiogenesis and tissue repair

Pathophysiol Haemost Thromb. 2006;35(1-2):162-5. doi: 10.1159/000093562.


Factor FXIII (FXIII) is a plasma transglutaminase that catalyzes the cross link formation between fibrin chains to stabilize the clot. Beside it s function in hemostasis FXIII has a role in wound healing and embryo implantation--processes that involve angiogenesis. In this review we discuss the role of FXIII in angiogenesis and the molecular mechanisms underlying its pro-angiogenic effect. In addition, FXIII role in wound repair is discussed.

Publication types

  • Review

MeSH terms

  • Factor XIII / physiology*
  • Factor XIII Deficiency
  • Homeostasis
  • Humans
  • Neovascularization, Physiologic / physiology*
  • Wound Healing / physiology*


  • Factor XIII