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, 50 (2), 381-3

Precursor B-cell Acute Lymphoblastic Leukemia Presenting With Hemophagocytic Lymphohistiocytosis

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Case Reports

Precursor B-cell Acute Lymphoblastic Leukemia Presenting With Hemophagocytic Lymphohistiocytosis

Maureen M O'Brien et al. Pediatr Blood Cancer.

Abstract

Hemophagocytic lymphohistiocytosis (HLH) is a hyperinflammatory syndrome which can be an inherited congenital disorder or can develop secondary to malignancy, infection, or autoimmune disease. Secondary HLH due to malignancy occurs most commonly with T or NK-cell lymphoid neoplasms. HLH with B-cell malignancies is less common and HLH has rarely been described in association with precursor B-cell acute lymphoblastic leukemia (B-ALL). We report three cases of HLH associated with B-ALL and review 17 cases of ALL-associated HLH previously reported in the literature.

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