Small-molecule screening made simple for a difficult target with a signaling nucleic acid aptamer that reports on deaminase activity

Angew Chem Int Ed Engl. 2006 Aug 25;45(34):5648-52. doi: 10.1002/anie.200601695.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenosine Deaminase / chemistry
  • Adenosine Deaminase Inhibitors*
  • Aptamers, Nucleotide / chemistry*
  • Binding Sites
  • Biosensing Techniques / methods*
  • Dose-Response Relationship, Drug
  • Enzyme Inhibitors* / chemistry
  • Enzyme Inhibitors* / pharmacology
  • Fluorescein / chemistry
  • Fluorescent Dyes / chemistry
  • Molecular Structure

Substances

  • Adenosine Deaminase Inhibitors
  • Aptamers, Nucleotide
  • Enzyme Inhibitors
  • Fluorescent Dyes
  • Adenosine Deaminase
  • Fluorescein