A German Fleckvieh calf was diagnosed with cyclopia in shape of united eye sockets in one orbit. However, two fully developed eye balls were present while the nostril was not developed. The malformed calf was inbred on a bull used for artificial insemination (AI) with an inbreeding coefficient of 3.125%. Teratogenic plant alkaloids were unlikely to be responsible for the malformation of this calf. Neither in the five progeny of the dam nor in the descendants of the AI-bull with a total of 8083 calvings, calves with such anomalies were found.