Initiation of meiotic recombination by formation of DNA double-strand breaks: mechanism and regulation

Biochem Soc Trans. 2006 Aug;34(Pt 4):523-5. doi: 10.1042/BST0340523.


Homologous recombination is essential for accurate chromosome segregation during meiosis in most sexual organisms. Meiotic recombination is initiated by the formation of DSBs (DNA double-strand breaks) made by the Spo11 protein. We review here recent findings pertaining to protein-protein interactions important for DSB formation, the mechanism of an early step in the processing of Spo11-generated DSBs, and regulation of DSB formation by protein kinases.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Nucleus / genetics
  • Cell Nucleus / metabolism
  • DNA / genetics*
  • DNA Damage / genetics*
  • Meiosis / genetics
  • Protein Binding
  • Recombination, Genetic / genetics*


  • DNA