Initiation of homologous chromosome pairing during meiosis

Biochem Soc Trans. 2006 Aug;34(Pt 4):545-9. doi: 10.1042/BST0340545.

Abstract

Following pre-meiotic DNA replication, homologous chromosomes must be paired and become tightly linked to ensure reductional segregation during meiosis I. Therefore initiation of homologous chromosome pairing is vital for meiosis to proceed correctly. A number of factors contribute to the initiation of homologous chromosome pairing including telomere and centromere dynamics, pairing centres, checkpoint proteins and components of the axial element. The present review briefly summarizes recent progress in our understanding of initiation of homologous chromosome pairing during meiosis and discusses the differences that are observed between research organisms.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Centromere / genetics
  • Chromosome Pairing / genetics*
  • DNA Damage / genetics
  • DNA Replication / genetics
  • Telomere / genetics