Dietary botanical diversity affects the reduction of oxidative biomarkers in women due to high vegetable and fruit intake

J Nutr. 2006 Aug;136(8):2207-12. doi: 10.1093/jn/136.8.2207.

Abstract

Many health benefits are associated with a high dietary intake of vegetables and fruit (VF); however, little effort has been expended to determine whether the botanical families from which high-VF diets are formulated affect their biological activities. The objective of this study was to determine whether the botanical diversity of high-VF diets alters the response in oxidative biomarkers for lipid peroxidation and DNA oxidation. Two diets were developed that varied in botanical diversity and provided 8-10 servings of VF/d. The high botanical diversity diet (HBD) included foods from the 18 botanical families that induced a reduction in oxidative damage of lipids or DNA. The low botanical diversity diet (LBD) emphasized 5 of these botanical families based on reports that their bioactive components had high antioxidant activity. A total of 106 women completed the study. Participants consumed 9.1 +/- 2.6 and 8.3 +/- 2.1 servings of VF/d with the LBD and HBD diets. Only the HBD diet induced a significant reduction in DNA oxidation (P < 0.05). Both the LBD and the HBD diets were associated with a reduction in lipid peroxidation (P < 0.01). These findings indicate that botanical diversity plays a role in determining the bioactivity of high-VF diets and that smaller amounts of many phytochemicals may have greater beneficial effects than larger amounts of fewer phytochemicals.

Publication types

  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biomarkers / blood
  • Biomarkers / urine
  • Carotenoids / blood
  • Diet*
  • Dinoprost / analogs & derivatives
  • Dinoprost / blood
  • Female
  • Fruit / classification*
  • Humans
  • Lipid Peroxidation*
  • Lymphocytes / metabolism
  • Middle Aged
  • Vasoconstrictor Agents / blood
  • Vegetables / classification*

Substances

  • Biomarkers
  • Vasoconstrictor Agents
  • 8-epi-prostaglandin F2alpha
  • Carotenoids
  • Dinoprost