HOX gene activation by retinoic acid

Trends Genet. 1991 Oct;7(10):329-34. doi: 10.1016/0168-9525(91)90423-n.


Vertebrate homeobox genes of the Hox family are, like Drosophila homeotic genes, organized in gene clusters and show a strict correspondence, or collinearity, between the order of the genes (3' to 5') within the chromosomal cluster and that of their expression domains (anterior to posterior) in the embryo. Recent data obtained from embryonal carcinoma cells induced to differentiate by retinoic acid cast some light on the molecular mechanisms underlying the collinear expression of the Hox genes.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Gene Expression Regulation*
  • Genes, Homeobox*
  • Humans
  • Molecular Sequence Data
  • Transcriptional Activation
  • Tretinoin / pharmacology*


  • Tretinoin