Combined immune deficiencies in children

J Infus Nurs. 2006 Jul-Aug;29(4):206-13. doi: 10.1097/00129804-200607000-00007.

Abstract

Combined immune deficiencies are a heterogeneous group of congenital disorders usually attributable to a single gene defect. The hallmark of these disorders is recurrent infections resulting from defects in both T- and B-cell function. This article reviews the basic components of the immune system as well as the clinical presentation, laboratory findings, and treatment for 3 distinct combined immune deficiencies.

Publication types

  • Review

MeSH terms

  • Algorithms
  • Anti-Bacterial Agents / therapeutic use
  • Antibody Formation / immunology
  • B-Lymphocytes / immunology
  • Bone Marrow Transplantation
  • Child
  • Decision Trees
  • DiGeorge Syndrome* / diagnosis
  • DiGeorge Syndrome* / etiology
  • DiGeorge Syndrome* / therapy
  • Fluid Therapy
  • Genetic Counseling
  • Humans
  • Immunoglobulin G / chemistry
  • Immunoglobulin G / immunology
  • Immunoglobulins, Intravenous / therapeutic use
  • Infections / drug therapy
  • Infections / etiology
  • Inheritance Patterns / genetics
  • Inheritance Patterns / immunology
  • Prognosis
  • Severe Combined Immunodeficiency* / diagnosis
  • Severe Combined Immunodeficiency* / etiology
  • Severe Combined Immunodeficiency* / therapy
  • Stem Cell Transplantation
  • T-Lymphocytes / immunology
  • Wiskott-Aldrich Syndrome* / diagnosis
  • Wiskott-Aldrich Syndrome* / etiology
  • Wiskott-Aldrich Syndrome* / therapy

Substances

  • Anti-Bacterial Agents
  • Immunoglobulin G
  • Immunoglobulins, Intravenous