Antiplatelet Agents, Carotid Endarterectomy, and Perioperative Complications

Neurosurg Focus. 2000 May 15;8(5):e1. doi: 10.3171/foc.2000.8.5.1.


Neurosurgeons are frequently involved in choosing an antiplatelet therapy for their patients in the perioperative period. New data obtained from the Aspirin and Carotid Endarterectomy (ACE) Trial suggest that low-dose aspirin is superior to high-dose aspirin therapy in reducing rates of perioperative stroke and death. The ACE-related data are reviewed, and the authors provide an update on current Food and Drug Administration-approved antiplatelet therapies for secondary stroke prevention, as well as a summary of antiplatelet therapies being developed.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Aspirin / therapeutic use
  • Endarterectomy, Carotid* / adverse effects
  • Humans
  • Intraoperative Complications / prevention & control*
  • Models, Biological
  • Platelet Aggregation Inhibitors / therapeutic use*
  • Stroke / drug therapy*
  • Stroke / etiology
  • Stroke / prevention & control*


  • Platelet Aggregation Inhibitors
  • Aspirin