Antiplatelet Agents, Carotid Endarterectomy, and Perioperative Complications

Neurosurg Focus. 2000 May 15;8(5):e1. doi: 10.3171/foc.2000.8.5.1.

Abstract

Neurosurgeons are frequently involved in choosing an antiplatelet therapy for their patients in the perioperative period. New data obtained from the Aspirin and Carotid Endarterectomy (ACE) Trial suggest that low-dose aspirin is superior to high-dose aspirin therapy in reducing rates of perioperative stroke and death. The ACE-related data are reviewed, and the authors provide an update on current Food and Drug Administration-approved antiplatelet therapies for secondary stroke prevention, as well as a summary of antiplatelet therapies being developed.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Aspirin / therapeutic use
  • Endarterectomy, Carotid* / adverse effects
  • Humans
  • Intraoperative Complications / prevention & control*
  • Models, Biological
  • Platelet Aggregation Inhibitors / therapeutic use*
  • Stroke / drug therapy*
  • Stroke / etiology
  • Stroke / prevention & control*

Substances

  • Platelet Aggregation Inhibitors
  • Aspirin