Toll-like receptor modulation in cardiovascular disease: a target for intervention?

Expert Opin Investig Drugs. 2006 Aug;15(8):857-71. doi: 10.1517/13543784.15.8.857.

Abstract

Toll-like receptors (TLRs) form a family of pattern recognition receptors that have emerged as key mediators of innate immunity. These receptors sense invading microbes and initiate the immune response. TLR-mediated inflammation is an important pathogenic link between innate immunity and a diverse panel of clinical disorders. Among the processes in which TLRs play a role are cardiovascular disorders such as cardiac ischaemia, coronary artery disease, ventricular remodelling, cancer angiogenesis or transplant rejection. From these, many important opportunities for disease modification through TLR signalling manipulation can be imagined. Their role as potential targets for therapeutic intervention is just beginning to be appreciated and this article reviews the current status of these treatment strategies for cardiovascular disease.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Anti-Inflammatory Agents / pharmacology
  • Anti-Inflammatory Agents / therapeutic use*
  • Atherosclerosis / drug therapy
  • Atherosclerosis / genetics
  • Atherosclerosis / metabolism
  • Cardiac Output, Low / drug therapy
  • Cardiac Output, Low / genetics
  • Cardiac Output, Low / metabolism
  • Cardiovascular Agents / pharmacology
  • Cardiovascular Agents / therapeutic use*
  • Cardiovascular Diseases / drug therapy*
  • Cardiovascular Diseases / genetics
  • Cardiovascular Diseases / metabolism
  • Clinical Trials as Topic
  • Genetic Predisposition to Disease
  • Humans
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors / pharmacology
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors / therapeutic use
  • Inflammation / drug therapy*
  • Inflammation / genetics
  • Inflammation / metabolism
  • Ligands
  • Polymorphism, Genetic
  • Signal Transduction
  • Toll-Like Receptor 2 / drug effects*
  • Toll-Like Receptor 2 / genetics
  • Toll-Like Receptor 2 / metabolism
  • Toll-Like Receptor 4 / drug effects*
  • Toll-Like Receptor 4 / genetics
  • Toll-Like Receptor 4 / metabolism
  • Toll-Like Receptor 5 / drug effects*
  • Toll-Like Receptor 5 / genetics
  • Toll-Like Receptor 5 / metabolism

Substances

  • Anti-Inflammatory Agents
  • Cardiovascular Agents
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors
  • Ligands
  • Toll-Like Receptor 2
  • Toll-Like Receptor 4
  • Toll-Like Receptor 5