Detection and classification of the mucosal and vascular patterns (mucosal morphology) in Barrett's esophagus by using narrow band imaging

Gastrointest Endosc. 2006 Aug;64(2):155-66. doi: 10.1016/j.gie.2005.11.049.


Background: The detection of the mucosal morphology (ie, mucosal and vascular patterns) in Barrett's esophagus (BE) by magnifying (chromo)endoscopy may improve the distinction of high-grade intraepithelial neoplasia (HGIN) from nondysplastic specialized intestinal metaplasia (SIM). Narrow band imaging (NBI) is a new technique that uses optical filters to enhance the mucosal contrast without the need for chromoendoscopy.

Objective: To use NBI for the characterization and the classification of the mucosal morphology in nondysplastic BE and in BE with HGIN.

Design: Descriptive study.

Setting: Single-center study in a tertiary referral center for the diagnosis and treatment of patients with BE.

Patients: We used NBI with magnifying endoscopy to image and biopsy randomly selected areas in 63 patients with BE. A systematic image and a biopsy specimen evaluation process was followed, including unblinded assessment of an exploratory set of images and biopsy specimens, and blinded evaluation of learning and validation sets.

Main outcome measurements: The relationship between the mucosal morphology and the presence of SIM and HGIN.

Results: SIM was characterized by either villous/gyrus-forming patterns (80%), which were mostly regular and had regular vascular patterns, or a flat mucosa with regular normal-appearing long branching vessels (20%). HGIN was characterized by 3 abnormalities: irregular/disrupted mucosal patterns, irregular vascular patterns, and abnormal blood vessels. All areas with HGIN had at least 1 abnormality, and 85% had 2 or more abnormalities. The frequency of abnormalities showed a significant rise with increasing grades of dysplasia. The magnified NBI images had a sensitivity of 94%, a specificity of 76%, a positive predictive value of 64%, and a negative predictive value of 98% for HGIN.

Limitations: No data on observer agreement.

Conclusions: NBI with magnification reveals the mucosal morphology characteristics of nondysplastic BE and HGIN, without the need for staining and has a relatively high diagnostic value for HGIN when used for targeted detailed examination of areas of interest.

MeSH terms

  • Aged
  • Barrett Esophagus / classification
  • Barrett Esophagus / diagnosis
  • Barrett Esophagus / pathology*
  • Endoscopy, Gastrointestinal / methods*
  • Esophagus / blood supply
  • Esophagus / pathology*
  • Female
  • Humans
  • Image Enhancement
  • Image Processing, Computer-Assisted
  • Logistic Models
  • Male
  • Middle Aged
  • Mucous Membrane / pathology
  • Risk Assessment
  • Sensitivity and Specificity