Pediatric multiple sclerosis: detection of clinically silent lesions by multimodal evoked potentials

J Pediatr. 2006 Jul;149(1):125-7. doi: 10.1016/j.jpeds.2006.01.003.


Pediatric patients with multiple sclerosis (MS) frequently do not meet MRI criteria for diagnosis because of lack of evidence of dissemination in space. We assessed the diagnostic utility of multimodal evoked potentials (EP). In 46% of 85 childhood patients with MS, spatial dissemination was detected by EP before the second clinical attack. EP may constitute an important tool for earlier diagnosis of pediatric MS.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Child
  • Evoked Potentials / physiology*
  • Female
  • Humans
  • Male
  • Multiple Sclerosis / diagnosis*
  • Multiple Sclerosis / physiopathology*
  • Neurologic Examination
  • Retrospective Studies