Chronic multifocal osteomyelitis, a new recessive mutation on chromosome 18 of the mouse

Genomics. 1991 Dec;11(4):794-8. doi: 10.1016/0888-7543(91)90002-v.


Mice with tail kinks and deformities in their lower extremities were observed in a litter of C.D2-Qa-2+N6F15 mice. A mutant line that exhibits this phenotype in 100% of its offspring was established by subsequent breeding. The abnormalities resembled to some degree those found in a human syndrome termed chronic recurrent multifocal osteomyelitis (CRMO). Accordingly, we name the new mutation chronic multifocal osteomyelitis (cmo). Breeding analysis showed that the defect was determined by a single autosomal recessive gene. Restriction fragment length polymorphism (RFLP) analysis of progeny from a backcross between Mus musculus domesticus (CLA) and C.D2-Qa-(2+)-cmo/cmo indicated that the cmo gene resides on mouse Chromosome 18.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Chromosome Mapping
  • Chronic Disease
  • Crosses, Genetic
  • Female
  • Genes, Recessive
  • Male
  • Mice
  • Mutation*
  • Osteomyelitis / genetics*
  • Phenotype
  • Polymorphism, Restriction Fragment Length