Pharmacologic interaction between cannabinol and delta9-tetrahydrocannabinol

Psychopharmacologia. 1975;41(3):277-84. doi: 10.1007/BF00428937.


The pharmacological activities of delta9-THC [(minus)-delta9-trans-tetrahydrocannabinol], CBN (Cannabinol) and mixtures of delta9-THC + CBN were studied in rabbits, rats and mice. CBN, although in general less active, mimicked the effects of delta9-THC in several pharmacological tests: corneal arreflexia in rabbits; climbing rope, open-field, irritability and aggressiveness after REM sleep deprivation in rats; catatonia, analgesia and sleeping time in mice. When the mixture delta9-THC + CBN was used, a synergistic effect occurred on most of the depressant effects. On the other hand CBN did not interfere with or slightly inhibited the excitatory effects of delta9-THC. In the one peripheral test used, CBN did not alter the delta9-THC effect.

MeSH terms

  • Aggression / drug effects
  • Analgesia
  • Animals
  • Behavior, Animal / drug effects
  • Cannabis / pharmacology*
  • Catatonia / chemically induced
  • Cornea / physiology
  • Dronabinol / pharmacology*
  • Drug Synergism
  • Exploratory Behavior / drug effects
  • Female
  • Humans
  • Male
  • Mice
  • Motor Skills / drug effects
  • Pentobarbital / pharmacology
  • Rabbits
  • Rats
  • Reflex / drug effects
  • Sleep / drug effects
  • Sleep Deprivation
  • Sleep, REM


  • Dronabinol
  • Pentobarbital