Structure-activity relationship study of 9-aminoacridine compounds in scrapie-infected neuroblastoma cells

Bioorg Med Chem Lett. 2006 Sep 15;16(18):4913-6. doi: 10.1016/j.bmcl.2006.06.050. Epub 2006 Jul 24.


A focused library of variously substituted 9-aminoacridine compounds was screened for bioactivity against accumulation of the infectious prion protein isoform, denoted PrP(Sc), in a cell model of prion replication. The efficacy of compounds against PrP(Sc) accumulation was influenced by both substituents of the distal tertiary amine and acridine heterocycle, while cellular cytotoxicity was encoded in the acridine heterocycle substituents.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aminacrine / chemistry*
  • Aminacrine / pharmacology*
  • Cell Line
  • Cell Survival / drug effects
  • Humans
  • Molecular Structure
  • Neuroblastoma / pathology*
  • Scrapie*
  • Structure-Activity Relationship


  • Aminacrine