Abstract
A novel, cell-surface protein essential for Ca(2+) release-activated Ca(2+) (CRAC) channel function has been identified through independent genome-wide screens. This huge advance will enable molecular dissection of the CRAC channel complex, moving the field beyond Icrac signature to structure.
MeSH terms
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Animals
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Calcium / metabolism*
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Calcium Channels / genetics*
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Calcium Channels / metabolism
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Drosophila / metabolism
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Drosophila Proteins / genetics
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Drosophila Proteins / metabolism
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Drosophila Proteins / physiology
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Genomics
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Humans
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Membrane Proteins / genetics
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Membrane Proteins / metabolism
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Membrane Proteins / physiology
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Models, Biological
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Multigene Family / physiology
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Mutation
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ORAI1 Protein
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RNA Interference
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T-Lymphocytes / metabolism
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T-Lymphocytes / physiology
Substances
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Calcium Channels
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Drosophila Proteins
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Membrane Proteins
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ORAI1 Protein
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ORAI1 protein, human
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olf186-F protein, Drosophila
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Calcium