Aurora-A amplification associated with BRCA2 mutation in breast tumours

Cancer Lett. 2007 Apr 8;248(1):96-102. doi: 10.1016/j.canlet.2006.06.003. Epub 2006 Jul 24.

Abstract

Potential interaction of Aurora-A amplification and BRCA2 mutation was examined in breast tumours from BRCA2 999del5 mutation carriers (n=20) and non-carriers (n=41). Aurora-A amplification studied by FISH was significantly more common in breast tumours from BRCA2 mutation carriers (p=0.0005). Extensive Aurora-A amplification was also detected on metaphase chromosomes in three breast epithelial cell lines with the same BRCA2 mutation. In addition, significant association was found between Aurora-A amplification and TP53 mutations in non-BRCA2 mutation carrier tumours (p=0.007). These results suggest that breast tumours with mutations in BRCA2 or TP53 could be promising candidates for Aurora-A targeted treatment.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aurora Kinases
  • BRCA2 Protein / genetics*
  • Breast Neoplasms / genetics
  • Breast Neoplasms / pathology*
  • Cell Line
  • DNA Mutational Analysis
  • Female
  • Gene Amplification*
  • Heterozygote
  • Humans
  • In Situ Hybridization, Fluorescence
  • Mutation*
  • Odds Ratio
  • Protein-Serine-Threonine Kinases / genetics*
  • Tumor Suppressor Protein p53 / genetics

Substances

  • BRCA2 Protein
  • Tumor Suppressor Protein p53
  • Aurora Kinases
  • Protein-Serine-Threonine Kinases