Functional specialization within the dorsolateral frontal cortex for serial order memory

Proc Biol Sci. 1991 Dec 23;246(1317):299-306. doi: 10.1098/rspb.1991.0158.


Monkeys with lesions restricted to two anatomically distinct regions of the dorsolateral frontal cortex were tested on a novel task that was developed to assess memory for the order of occurrence of stimuli. Monkeys with bilateral lesions of the mid-dorsolateral frontal cortex (cytoarchitectonic areas 46 and 9) were severely impaired, whereas monkeys with lesions of the posterior region of the dorsolateral frontal cortex (area 8 and rostral area 6) performed as well as the normal control animals. These results show that the primate mid-dorsolateral frontal cortex is a critical component of a neural circuit underlying the monitoring of the serial order of stimuli.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Brain Mapping
  • Frontal Lobe / anatomy & histology
  • Frontal Lobe / physiology*
  • Learning
  • Macaca nemestrina
  • Male
  • Memory / physiology*
  • Reward