Sedating effects of Humulus lupulus L. extracts

Phytomedicine. 2006 Sep;13(8):535-41. doi: 10.1016/j.phymed.2006.05.010. Epub 2006 Jul 24.


It was the aim of the study to check ethanolic and CO2 extracts from Humulus lupulus for sedating activity. Both preparations reduced the spontaneous locomotor activity, increased the ketamine-induced sleeping time and reduced body temperature, confirming a central sedating effect. No indications of anxiolytic activity were found in the elevated plus maze test for any of the test preparations. This sedating activity could be attributed to three categories of constituents of lipophilic hops extracts. Though the alpha-bitter acids proved to the be most active constituents, the beta-bitter acids and the hop oil clearly contributed to the sedating activity of lipophilic Humulus extracts.

MeSH terms

  • Animals
  • Anti-Anxiety Agents / analysis
  • Body Temperature / drug effects
  • Female
  • Humulus / chemistry*
  • Hypnotics and Sedatives / pharmacology*
  • Mice
  • Motor Activity / drug effects*
  • Plant Extracts / pharmacology*
  • Sleep / drug effects*


  • Anti-Anxiety Agents
  • Hypnotics and Sedatives
  • Plant Extracts