Adherence to treatment in patients with epilepsy: associations with seizure control and illness beliefs

Seizure. 2006 Oct;15(7):504-8. doi: 10.1016/j.seizure.2006.06.003. Epub 2006 Jul 24.


Objective: This study investigated non-adherence to antiepileptic drug treatment amongst patients with epilepsy in secondary care. The associations between adherence and seizure control, perceptions of illness and medication, anxiety and depression were also examined.

Methods: A cross-sectional study of fifty-four patients with epilepsy were recruited from a hospital epilepsy clinic.

Results: Fifty-nine percent were estimated to be non-adherent to medication. There was a negative correlation between adherence and frequency of seizures. Patients with poorly controlled epilepsy were more anxious, and expected a longer duration of their epilepsy.

Conclusion: Assessment of adherence should be a routine part of management of epilepsy. Further recognition and support should be given to patients who have poor seizure control since they are more likely to be more anxious and have unhelpful illness and treatment beliefs.

MeSH terms

  • Adult
  • Anticonvulsants / therapeutic use*
  • Attitude to Health*
  • Cross-Sectional Studies
  • Epilepsy / drug therapy*
  • Epilepsy / psychology
  • Female
  • Humans
  • Male
  • Patient Compliance*
  • Surveys and Questionnaires*


  • Anticonvulsants