Expression of ADP-ribosylation factor-like protein 8B mRNA in the brain is down-regulated in mice fed a high-fat diet

Biosci Biotechnol Biochem. 2006 Jul;70(7):1798-802. doi: 10.1271/bbb.60168.


A differential display was performed to analyze differential gene expression in the brains of mice in association with dietary high beef-tallow. Consumption of a high beef-tallow diet downregulated the expression of ADP-ribosylation factor-like protein 8B (Arl8B) mRNA in the brain. Arl8B mRNA was widely expressed in the mouse brain, including primary neuronal cells. The current study indicates that green fluorescent protein-fused Arl8B protein accumulated at the growth cones in primary neuronal cells, and that protrusions of human embryonic kidney 293 (HEK293) cells were significantly elongated by overexpression of Arl8B, suggesting an important role of Arl8B in neurite formation.

MeSH terms

  • ADP-Ribosylation Factors / biosynthesis*
  • Animals
  • Brain / metabolism*
  • Cells, Cultured
  • Dietary Fats / administration & dosage*
  • Down-Regulation
  • Gene Expression Profiling
  • Growth Cones / physiology
  • Humans
  • Male
  • Mice
  • Mice, Inbred ICR
  • Neurons / metabolism
  • RNA, Messenger / biosynthesis
  • Recombinant Fusion Proteins / biosynthesis
  • Reverse Transcriptase Polymerase Chain Reaction


  • ARL8B protein, human
  • Dietary Fats
  • RNA, Messenger
  • Recombinant Fusion Proteins
  • ADP-Ribosylation Factors