Practice parameter: prediction of outcome in comatose survivors after cardiopulmonary resuscitation (an evidence-based review): report of the Quality Standards Subcommittee of the American Academy of Neurology

Neurology. 2006 Jul 25;67(2):203-10. doi: 10.1212/


Objective: To systematically review outcomes in comatose survivors after cardiac arrest and cardiopulmonary resuscitation (CPR).

Methods: The authors analyzed studies (1966 to 2006) that explored predictors of death or unconsciousness after 1 month or unconsciousness or severe disability after 6 months.

Results: The authors identified four class I studies, three class II studies, and five class III studies on clinical findings and circumstances. The indicators of poor outcome after CPR are absent pupillary light response or corneal reflexes, and extensor or no motor response to pain after 3 days of observation (level A), and myoclonus status epilepticus (level B). Prognosis cannot be based on circumstances of CPR (level B) or elevated body temperature (level C). The authors identified one class I, one class II, and nine class III studies on electrophysiology. Bilateral absent cortical responses on somatosensory evoked potential studies recorded 3 days after CPR predicted poor outcome (level B). Burst suppression or generalized epileptiform discharges on EEG predicted poor outcomes but with insufficient prognostic accuracy (level C). The authors identified one class I, 11 class III, and three class IV studies on biochemical markers. Serum neuron-specific enolase higher than 33 microg/L predicted poor outcome (level B). Ten class IV studies on brain monitoring and neuroimaging did not provide data to support or refute usefulness in prognostication (level U).

Conclusion: Pupillary light response, corneal reflexes, motor responses to pain, myoclonus status epilepticus, serum neuron-specific enolase, and somatosensory evoked potential studies can reliably assist in accurately predicting poor outcome in comatose patients after cardiopulmonary resuscitation for cardiac arrest.

Publication types

  • Review

MeSH terms

  • Cardiopulmonary Resuscitation / statistics & numerical data*
  • Clinical Trials as Topic / statistics & numerical data
  • Coma / epidemiology*
  • Coma / therapy*
  • Evidence-Based Medicine / statistics & numerical data
  • Humans
  • Outcome Assessment, Health Care / methods*
  • Outcome Assessment, Health Care / standards
  • Practice Guidelines as Topic
  • Practice Patterns, Physicians' / standards
  • Risk Assessment / methods*
  • Risk Factors
  • Survival Analysis*
  • Survival Rate
  • Survivors / statistics & numerical data*
  • United States / epidemiology