Revisiting normal (51)Cr-ethylenediaminetetraacetic acid clearance values in children

Eur J Nucl Med Mol Imaging. 2006 Dec;33(12):1477-82. doi: 10.1007/s00259-006-0179-2. Epub 2006 Jul 25.

Abstract

Purpose: Normal (51)Cr-ethylenediaminetetraacetic acid (EDTA) clearance values as a function of age were published a number of years ago. These values were based on data from children with a normal left to right ratio and a normal appearance on DMSA scintigraphy, despite the presence of an acute renal infection. At that time, the authors were unaware that hyperfiltration is a common phenomenon in patients with acute renal infection and that their normal values could have been significantly overestimated. The present work therefore aimed to re-appraise these normal values.

Methods: In a first step, in order to verify the previous results, the same type of population was selected, namely patients with present or past urinary tract infection but normal images and a normal left to right ratio on DMSA scintigraphy. In a second step, the selection was based on patients who had had no recent urinary tract infection. In both series, a single blood sample method was used for the evaluation of (51)Cr-EDTA clearance.

Results: In the first group of patients, the results obtained were almost identical to those previously published. In the second group of patients, the results were significantly lower: after 2 years of age, the mean GFR value was 104 ml/min/1.73 m(2) (10th and 90th percentiles 81 and 135 ml/min/1.73 m(2), respectively), compared with 117 ml/min/1.73 m(2) in the first group.

Conclusion: The data of the second group are probably more representative of the true normal GFR values and can be applied to the entire paediatric population.

MeSH terms

  • Adolescent
  • Age Factors
  • Child
  • Child, Preschool
  • Chromium Radioisotopes / chemistry
  • Edetic Acid / chemistry*
  • Edetic Acid / pharmacokinetics*
  • Glomerular Filtration Rate
  • Humans
  • Infant
  • Infant, Newborn
  • Kidney / diagnostic imaging
  • Kidney / physiopathology
  • Metabolic Clearance Rate
  • Radioisotope Renography
  • Reference Values
  • Retrospective Studies
  • Technetium Tc 99m Dimercaptosuccinic Acid
  • Urinary Tract Infections / diagnostic imaging
  • Urinary Tract Infections / metabolism

Substances

  • Chromium Radioisotopes
  • Technetium Tc 99m Dimercaptosuccinic Acid
  • Edetic Acid