Structure of the human telomere in K+ solution: an intramolecular (3 + 1) G-quadruplex scaffold

J Am Chem Soc. 2006 Aug 2;128(30):9963-70. doi: 10.1021/ja062791w.


We present the intramolecular G-quadruplex structure of human telomeric DNA in physiologically relevant K(+) solution. This G-quadruplex, whose (3 + 1) topology differs from folds reported previously in Na(+) solution and in a K(+)-containing crystal, involves the following: one anti.syn.syn.syn and two syn.anti.anti.anti G-tetrads; one double-chain reversal and two edgewise loops; three G-tracts oriented in one direction and the fourth in the opposite direction. The topological characteristics of this (3 + 1) G-quadruplex scaffold should provide a unique platform for structure-based anticancer drug design targeted to human telomeric DNA.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • DNA / chemistry*
  • G-Quadruplexes
  • Guanine / chemistry
  • Humans
  • Models, Molecular
  • Nucleic Acid Conformation
  • Potassium / chemistry*
  • Solutions / chemistry
  • Telomere / chemistry*


  • Solutions
  • Guanine
  • DNA
  • Potassium

Associated data

  • PDB/2GKU