Yawning produced by dopamine agonists in rhesus monkeys

Eur J Pharmacol. 1991 Aug 29;201(2-3):235-8. doi: 10.1016/0014-2999(91)90351-p.

Abstract

Yawning was recorded from five rhesus monkeys restrained in a chair after i.m. injection of dopaminergic compounds: apomorphine (0.03 mg/kg), quinpirole (0.01 mg/kg), and (-)-3-(3-hydroxyphenyl)-N-(1-propyl)piperidine (1 mg/kg). SKF 38393 or physostigmine produced no yawning. Yawning from apomorphine was blocked by chlorpromazine or SCH 23390 (0.03 mg/kg). Sulpiride (10 mg/kg) was ineffective. The difference between rats and monkeys in their yawning response to dopaminergic compounds is discussed.

MeSH terms

  • 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine / pharmacology
  • Animals
  • Antipsychotic Agents / pharmacology
  • Apomorphine / antagonists & inhibitors
  • Apomorphine / pharmacology
  • Benzazepines / pharmacology
  • Dopamine / physiology*
  • Dopamine Agents / pharmacology
  • Dopamine Antagonists
  • Ergolines / pharmacology
  • Macaca mulatta
  • Male
  • Physostigmine / pharmacology
  • Piperidines / pharmacology
  • Quinpirole
  • Receptors, Dopamine / drug effects
  • Receptors, Dopamine D1
  • Receptors, Dopamine D2
  • Yawning / drug effects*

Substances

  • Antipsychotic Agents
  • Benzazepines
  • Dopamine Agents
  • Dopamine Antagonists
  • Ergolines
  • Piperidines
  • Receptors, Dopamine
  • Receptors, Dopamine D1
  • Receptors, Dopamine D2
  • Quinpirole
  • 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine
  • Physostigmine
  • preclamol
  • Apomorphine
  • Dopamine