DEFB1 gene polymorphisms and increased risk of HIV-1 infection in Brazilian children

AIDS. 2006 Aug 1;20(12):1673-5. doi: 10.1097/01.aids.0000238417.05819.40.

Abstract

In our study we analysed three single nucleotide polymorphisms (SNPs) in the 5' untranslated region (UTR) of the DEFB1 gene, namely -52(G/A) -44(C/G) and -20(G/A), in three groups of northeastern Brazilian children in order to assess their role in HIV-1 infection. Our results allowed us to hypothesize that the SNPs located in the 5' UTR of the DEFB1 gene can be employed as a marker of risk for HIV-1 infection.

MeSH terms

  • Adolescent
  • Anti-Infective Agents
  • Brazil / epidemiology
  • Child
  • Child, Preschool
  • Gene Frequency
  • Genetic Markers / genetics
  • Genotype
  • HIV Infections / epidemiology
  • HIV Infections / genetics*
  • HIV-1*
  • Humans
  • Infant
  • Polymorphism, Single Nucleotide / genetics*
  • Risk Factors
  • beta-Defensins / genetics*

Substances

  • Anti-Infective Agents
  • DEFB1 protein, human
  • Genetic Markers
  • beta-Defensins