Total synthesis of (-)-spongidepsin

Laurent Ferrié; Sébastien Reymond; Patrice Capdevielle; Janine Cossy

doi:10.1021/ol061029w

Total synthesis of (-)-spongidepsin

Org Lett. 2006 Aug 3;8(16):3441-3. doi: 10.1021/ol061029w.

Authors

Laurent Ferrié¹, Sébastien Reymond, Patrice Capdevielle, Janine Cossy

Affiliation

¹ ESPCI, Laboratoire de Chimie Organique, 10 Rue Vauquelin, 75231 Paris Cedex 05, France.

PMID: 16869630
DOI: 10.1021/ol061029w

Abstract

[structure: see text] A convergent and rapid stereoselective synthesis of (-)-spongidepsin has been achieved from the Roche ester in 14 steps with an overall yield of 13%.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Depsipeptides / chemical synthesis*
Depsipeptides / chemistry
Molecular Structure
Porifera / chemistry
Stereoisomerism

Substances

Depsipeptides
spongidepsin