Synthesis and identification of a novel tetrazole metabolite of the angiotensin II receptor antagonist DuP 753

Drug Metab Dispos. Nov-Dec 1991;19(6):1160-2.
No abstract available

Publication types

  • Comparative Study

MeSH terms

  • Angiotensin II / antagonists & inhibitors*
  • Angiotensin Receptor Antagonists*
  • Animals
  • Biotransformation
  • Biphenyl Compounds / metabolism*
  • Biphenyl Compounds / pharmacokinetics
  • Chromatography, High Pressure Liquid
  • Glucuronates / chemical synthesis
  • Glucuronates / metabolism
  • Glucuronates / pharmacokinetics
  • Haplorhini
  • Imidazoles / metabolism*
  • Imidazoles / pharmacokinetics
  • Liver / anatomy & histology
  • Liver / metabolism
  • Losartan
  • Magnetic Resonance Spectroscopy / methods
  • Spectrophotometry, Ultraviolet
  • Spectrum Analysis
  • Tetrazoles / chemical synthesis*
  • Tetrazoles / metabolism*
  • Tetrazoles / pharmacokinetics

Substances

  • Angiotensin Receptor Antagonists
  • Biphenyl Compounds
  • Glucuronates
  • Imidazoles
  • Tetrazoles
  • Angiotensin II
  • Losartan