Abstract
We report herein the SAR studies of a series of indole-imidazole compounds. that demonstrate substantial in vitro anti-proliferative activities against cancer cell lines, including multidrug resistance (MDR) phenotypes. The in vitro cytotoxic effects have been demonstrated across a wide array of tumor types, including hematologic and solid tumor cell lines of various origins (e.g., leukemia, breast, colon, and uterine).
MeSH terms
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Antineoplastic Agents / chemical synthesis*
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Antineoplastic Agents / pharmacology
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Cell Death / drug effects
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Cell Line, Tumor
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Drug Resistance, Multiple*
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Humans
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Imidazoles / chemical synthesis*
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Imidazoles / pharmacology
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Indoles / chemical synthesis*
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Indoles / pharmacology
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Inhibitory Concentration 50
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Neoplasms / drug therapy
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Neoplasms / pathology
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Structure-Activity Relationship
Substances
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Antineoplastic Agents
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Imidazoles
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Indoles