Lyme Myositis

Arthritis Rheum. 2006 Aug;54(8):2697-700. doi: 10.1002/art.22007.


Myositis has been reported as a rare manifestation of Lyme disease, and Lyme myositis can be an important consideration in the differential diagnosis of unusual cases, especially in patients who live in or travel to endemic areas. We report the case of a 43-year-old man who presented with focal myositis of the proximal lower extremity and was subsequently diagnosed as having Lyme myositis. The patient had previously experienced a febrile illness and rash, but had no ongoing symptoms of Lyme disease. Myositis was confirmed by magnetic resonance imaging and muscle biopsy; Borrelia burgdorferi infection was confirmed by Lyme serology and polymerase chain reaction testing of synovial fluid and biopsy material. The current case is reviewed in the context of findings from previous case descriptions.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Anti-Bacterial Agents / therapeutic use
  • Antibodies, Bacterial / blood
  • Borrelia burgdorferi / genetics
  • Borrelia burgdorferi / immunology
  • Borrelia burgdorferi / isolation & purification*
  • Ceftriaxone / therapeutic use
  • DNA, Bacterial / analysis
  • Humans
  • Lower Extremity / pathology
  • Lyme Disease / complications
  • Lyme Disease / diagnosis*
  • Lyme Disease / drug therapy
  • Magnetic Resonance Imaging
  • Male
  • Myositis / diagnosis*
  • Myositis / drug therapy
  • Myositis / etiology
  • Reference Values
  • Treatment Outcome


  • Anti-Bacterial Agents
  • Antibodies, Bacterial
  • DNA, Bacterial
  • Ceftriaxone