Design and synthesis of highly potent and selective pharmacological chaperones for the treatment of Gaucher's disease

Chembiochem. 2006 Sep;7(9):1356-9. doi: 10.1002/cbic.200600217.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • 1-Deoxynojirimycin / analogs & derivatives
  • 1-Deoxynojirimycin / chemistry
  • Catalysis
  • Drug Design*
  • Enzyme Inhibitors / chemical synthesis
  • Enzyme Inhibitors / chemistry*
  • Enzyme Inhibitors / pharmacology
  • Fibroblasts / drug effects
  • Fibroblasts / enzymology
  • Gaucher Disease / drug therapy*
  • Glucan 1,4-alpha-Glucosidase / antagonists & inhibitors
  • Glucan 1,4-alpha-Glucosidase / chemistry
  • Glucosidases / antagonists & inhibitors
  • Glucosidases / chemistry
  • Glucosylceramidase / antagonists & inhibitors
  • Glucosylceramidase / chemistry
  • Glucosylceramidase / drug effects
  • Humans
  • Imines / chemistry
  • Xylitol / analogs & derivatives
  • Xylitol / chemistry

Substances

  • Enzyme Inhibitors
  • Imines
  • 1-Deoxynojirimycin
  • Glucosidases
  • Glucan 1,4-alpha-Glucosidase
  • Glucosylceramidase
  • Xylitol