Quantitative approaches to the analysis of the control and regulation of microbial metabolism

Antonie Van Leeuwenhoek. Oct-Nov 1991;60(3-4):193-207. doi: 10.1007/BF00430365.


Recently, a number of novel ways of considering the control, regulation and thermodynamics of microbial physiology have been developed and applied. We here present an overview of the new concepts involved, of their limitations and of the most recent attempts to deal with those limitations. We conclude that there no longer exist reasons of principle for vagueness in discussions of the control of microbial physiology and energetics. Further, the novel conceptual methods serve to remove part of the discordance between holistic and reductionistic views of microbial physiology.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adenosine Monophosphate / metabolism
  • Bacteria / metabolism*
  • Bacterial Physiological Phenomena
  • Bacteriological Techniques
  • Energy Metabolism
  • Escherichia coli / enzymology*
  • Glutamate-Ammonia Ligase / metabolism
  • Mathematics
  • Models, Biological


  • Adenosine Monophosphate
  • Glutamate-Ammonia Ligase