Knocking down disease with siRNAs

Cell. 2006 Jul 28;126(2):231-5. doi: 10.1016/j.cell.2006.07.007.

Abstract

Knocking down expression of disease-related genes using small interfering RNAs (siRNAs) has potential for treating a variety of illnesses. This Essay will examine the opportunities for harnessing RNA interference (RNAi) for therapy, as well as the obstacles and possible ways to circumvent them.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Animals
  • Drug Delivery Systems / methods*
  • Gene Silencing / drug effects
  • Genetic Therapy / methods
  • Humans
  • Infections / therapy*
  • Neoplasms / therapy*
  • RNA Interference*
  • RNA, Small Interfering* / administration & dosage
  • RNA, Small Interfering* / chemistry
  • RNA, Small Interfering* / genetics
  • RNA, Small Interfering* / metabolism
  • RNA, Small Interfering* / pharmacokinetics
  • RNA, Small Interfering* / therapeutic use

Substances

  • RNA, Small Interfering