doi: 10.1016/0006-8993(91)91474-f.
Non-opioid antitussives inhibit endogenous glutamate release from rabbit hippocampal slices
Affiliations
- PMID: 1687377
- DOI: 10.1016/0006-8993(91)91474-f
Item in Clipboard
Non-opioid antitussives inhibit endogenous glutamate release from rabbit hippocampal slices
Brain Res.
.
Abstract
The non-opioid antitussive drugs, dextromethorphan, caramiphen and carbetapentane, are also anticonvulsant. The effects of these antitussives on potassium-stimulated release of endogenous amino acids from rabbit hippocampal slices was tested. All 3 drugs significantly reduced the release of glutamate, with carbetapentane being the most potent (IC50 approximately 40 microM). We suggest that the anticonvulsant action may be due to their ability to decrease glutamate release.
Similar articles
-
Effects of non-opioid antitussives on hypoxia-induced electrical changes in rat hippocampal slices: a comparative study with anticonvulsant drugs.Gen Pharmacol. 1993 Jul;24(4):991-8. doi: 10.1016/0306-3623(93)90178-z. Gen Pharmacol. 1993. PMID: 8224752
-
Effects of non-opioid antitussives on epileptiform activity and NMDA responses in hippocampal and olfactory cortex slices.Brain Res. 1990 Oct 8;529(1-2):277-85. doi: 10.1016/0006-8993(90)90838-3. Brain Res. 1990. PMID: 2282497
-
Dextromethorphan and carbetapentane: centrally acting non-opioid antitussive agents with novel anticonvulsant properties.Brain Res. 1986 Sep 24;383(1-2):314-8. doi: 10.1016/0006-8993(86)90031-4. Brain Res. 1986. PMID: 3768695
-
Discriminative stimulus properties of dextromethorphan in rats.Biomed Pharmacother. 1995;49(10):456-64. doi: 10.1016/0753-3322(96)82690-4. Biomed Pharmacother. 1995. PMID: 8746072 Review.
-
Allosteric modulation of dextromethorphan binding sites.Neuropharmacology. 1987 Jul;26(7B):997-1001. doi: 10.1016/0028-3908(87)90078-5. Neuropharmacology. 1987. PMID: 2821439 Review.
Cited by
-
Full Protection Against Soman-Induced Seizures and Brain Damage by LY293558 and Caramiphen Combination Treatment in Adult Rats.Neurotox Res. 2018 Oct;34(3):511-524. doi: 10.1007/s12640-018-9907-1. Epub 2018 Apr 30. Neurotox Res. 2018. PMID: 29713995
-
Comparing the Antiseizure and Neuroprotective Efficacy of LY293558, Diazepam, Caramiphen, and LY293558-Caramiphen Combination against Soman in a Rat Model Relevant to the Pediatric Population.J Pharmacol Exp Ther. 2018 May;365(2):314-326. doi: 10.1124/jpet.117.245969. Epub 2018 Feb 21. J Pharmacol Exp Ther. 2018. PMID: 29467308 Free PMC article.
-
Neuroprotective efficacy of caramiphen against soman and mechanisms of its action.Br J Pharmacol. 2011 Nov;164(5):1495-505. doi: 10.1111/j.1476-5381.2011.01427.x. Br J Pharmacol. 2011. PMID: 21486285 Free PMC article.
-
Blockade by sigma site ligands of high voltage-activated Ca2+ channels in rat and mouse cultured hippocampal pyramidal neurones.Br J Pharmacol. 1995 Dec;116(7):2801-10. doi: 10.1111/j.1476-5381.1995.tb15929.x. Br J Pharmacol. 1995. PMID: 8680709 Free PMC article.
-
Lithium stimulates glutamate "release" and inositol 1,4,5-trisphosphate accumulation via activation of the N-methyl-D-aspartate receptor in monkey and mouse cerebral cortex slices.Proc Natl Acad Sci U S A. 1994 Aug 30;91(18):8358-62. doi: 10.1073/pnas.91.18.8358. Proc Natl Acad Sci U S A. 1994. PMID: 8078888 Free PMC article.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
