Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
, 113 (4), 1435-49

Pax-6, a Murine Paired Box Gene, Is Expressed in the Developing CNS

Affiliations
  • PMID: 1687460

Pax-6, a Murine Paired Box Gene, Is Expressed in the Developing CNS

C Walther et al. Development.

Abstract

A multigene family of paired-box-containing genes (Pax genes) has been identified in the mouse. In this report, we describe the expression pattern of Pax-6 during embryogenesis and the isolation of cDNA clones spanning the entire coding region. The Pax-6 protein consists of 422 amino acids as deduced from the longest open reading frame and contains, in addition to the paired domain, a paired-type homeodomain. Beginning with day 8 of gestation, Pax-6 is expressed in discrete regions of the forebrain and the hindbrain. In the neural tube, expression is mainly confined to mitotic active cells in the ventral ventricular zone along the entire anteroposterior axis starting at day 8.5 of development. Pax-6 is also expressed in the developing eye, the pituitary and the nasal epithelium.

Similar articles

See all similar articles

Cited by 298 articles

See all "Cited by" articles

Publication types

LinkOut - more resources

Feedback