Pax-6, a murine paired box gene, is expressed in the developing CNS

Development. 1991 Dec;113(4):1435-49. doi: 10.1242/dev.113.4.1435.


A multigene family of paired-box-containing genes (Pax genes) has been identified in the mouse. In this report, we describe the expression pattern of Pax-6 during embryogenesis and the isolation of cDNA clones spanning the entire coding region. The Pax-6 protein consists of 422 amino acids as deduced from the longest open reading frame and contains, in addition to the paired domain, a paired-type homeodomain. Beginning with day 8 of gestation, Pax-6 is expressed in discrete regions of the forebrain and the hindbrain. In the neural tube, expression is mainly confined to mitotic active cells in the ventral ventricular zone along the entire anteroposterior axis starting at day 8.5 of development. Pax-6 is also expressed in the developing eye, the pituitary and the nasal epithelium.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Brain / embryology
  • Brain / physiology
  • Central Nervous System / embryology*
  • Central Nervous System / physiology
  • Cloning, Molecular
  • DNA, Circular / genetics
  • Eye / embryology
  • Gene Expression / physiology*
  • Genes, Homeobox / genetics*
  • Mice
  • Mice, Inbred Strains
  • Microscopy, Electron
  • Molecular Sequence Data
  • Morphogenesis / genetics


  • DNA, Circular