MDM2 309T>G polymorphism and risk of lung cancer in a Korean population

Lung Cancer. 2006 Oct;54(1):19-24. doi: 10.1016/j.lungcan.2006.06.008. Epub 2006 Jul 27.


Background: The MDM2 protein plays an important role in regulating cell proliferation and apoptosis by interaction with multiple proteins including p53 and Rb. A polymorphism (309T>G) in the MDM2 promoter has been shown to result in higher levels of MDM2 RNA and protein. In order to evaluate the association of the MDM2 309T>G polymorphism and lung cancer risk, we carried out a case-control study in a Korean population.

Methods: The MDM2 genotypes were determined in 582 lung cancer patients and in 582 healthy control subjects who were frequency matched for age and gender.

Results: The distribution of the MDM2 309T>G genotypes was not significantly different between overall lung cancer cases and controls. However, when the cases were categorized by tumor histology, the 309GG genotype was associated with a significantly increased risk of adenocarcinoma (adjusted OR=1.91, 95% CI=1.16-3.14, P=0.01) compared to the 309TT genotype. In addition, the risk of adenocarcinoma increased as the number of 309G alleles increased (P(trend)=0.01).

Conclusion: Our findings suggest that the MDM2 309T>G polymorphism may be used as a marker for genetic susceptibility to adenocarcinoma of the lung.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenocarcinoma / genetics*
  • Adenocarcinoma / pathology
  • Alleles
  • Case-Control Studies
  • Chi-Square Distribution
  • Female
  • Genetic Predisposition to Disease
  • Genotype
  • Humans
  • Korea
  • Logistic Models
  • Lung Neoplasms / genetics*
  • Lung Neoplasms / pathology
  • Male
  • Middle Aged
  • Polymorphism, Genetic*
  • Promoter Regions, Genetic
  • Proto-Oncogene Proteins c-mdm2 / genetics*
  • Risk Factors


  • MDM2 protein, human
  • Proto-Oncogene Proteins c-mdm2