Transcriptional regulation of liver-specific gene expression

Curr Opin Cell Biol. 1991 Dec;3(6):960-5. doi: 10.1016/0955-0674(91)90114-e.


Liver-specific gene expression is regulated by four families of transcriptional activatory proteins that are not liver-specific, but are still restricted to a subset of tissues. The current opinion is that liver-specificity is a consequence of the combinatorial action of these factors, which could represent 'functional compartments' coexisting in the hepatocyte.

Publication types

  • Review

MeSH terms

  • Animals
  • Apolipoprotein A-I
  • Base Sequence
  • Gene Expression Regulation*
  • Genes, Homeobox
  • Liver / metabolism*
  • Molecular Sequence Data
  • Multigene Family
  • Transcription Factors
  • Transcription, Genetic*
  • Transcriptional Activation


  • Apolipoprotein A-I
  • Transcription Factors