The multi-ethnic pediatric eye disease study: design and methods

Ophthalmic Epidemiol. 2006 Aug;13(4):253-62. doi: 10.1080/09286580600719055.


Purpose: To summarize the study design of the Multi-Ethnic Pediatric Eye Disease Study (MEPEDS).

Methods: The objectives of the MEPEDS are to: (1) estimate age- and ethnicity-specific prevalence of strabismus, amblyopia, and refractive error; (2) evaluate the association of selected risk factors with these ocular disorders; and (3) evaluate the association of ocular conditions on limitations in health-related functional status in a population-based sample of 12,000 children aged 6-72 months from four ethnic groups--African-American, Asian-American, Hispanics/Latinos and non-Hispanic White. Each eligible child undergoes an eye examination, which includes an interview with his/her parent. The interview includes an assessment of demographic, behavioral, biological, and ocular risk factors and health-related functional status. The examination includes fixation preference testing, visual acuity, stereoacuity, axial length measurement, cycloplegic refraction, keratometry, eye alignment, and anterior and posterior segment examination.

Publication types

  • Comparative Study
  • Multicenter Study
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amblyopia / ethnology*
  • California / epidemiology
  • Child, Preschool
  • Ethnic Groups*
  • Female
  • Humans
  • Infant
  • Male
  • Prevalence
  • Prognosis
  • Refractive Errors / ethnology*
  • Research Design
  • Risk Factors
  • Strabismus / ethnology*