Pedimune in recurrent respiratory infection and diarrhoea--the Indian experience--the pride study

Indian J Pediatr. 2006 Jul;73(7):585-91. doi: 10.1007/BF02759923.


Objective: To evaluate the efficacy and tolerability of bovine colostrum in preventing recurrent episodes of upper respiratory tract infections and diarrhoea in children

Methods: 605 children (1-8 yrs) having recurrent episodes of upper respiratory tract infections or diarrhea received Bovine Colostrum (Pedimune) for 12 weeks. Total no of episodes of recurrent infections, hospitalization rate, overall well being and adverse events were assessed at every 4 weeks.

Results: Episodes of URTI and diarrhoea reduced significantly by 91.19 % and 86.60% at the end of therapy respectively. High to average improvement in overall well-being in 96 % of the patients were found by pediatrician while overall well-being stated by the patient/care taker was very good to good in 90.56 % of the patients.

Conclusion: Bovine colostrum was highly effective in the prophylactic treatment of recurrent URTIs and diarrhea in reducing not only the episodes but also the hospitalization due to them.

Publication types

  • Clinical Trial
  • Multicenter Study

MeSH terms

  • Child
  • Child, Preschool
  • Colostrum / immunology*
  • Diarrhea / drug therapy*
  • Diarrhea / immunology
  • Female
  • Hospitalization
  • Humans
  • Immunologic Factors / immunology*
  • India
  • Infant
  • Male
  • Recurrence
  • Respiratory Tract Infections / drug therapy*
  • Respiratory Tract Infections / immunology


  • Immunologic Factors