A large noncoding RNA is a marker for murine hepatocellular carcinomas and a spectrum of human carcinomas

Oncogene. 2007 Feb 8;26(6):851-8. doi: 10.1038/sj.onc.1209846. Epub 2006 Jul 31.


Tumor markers can facilitate understanding molecular cell biology of neoplasia and provide potential targets for the diagnosis and insight for intervention. We here identify a novel murine gene, hepcarcin (hcn), encoding a 7-kb mRNA-like transcript. The gene appears to be the murine ortholog of the human alpha gene, that is, MALAT-1. The gene and homologs lack credible open reading frames, consistent with a highly conserved large noncoding RNA (ncRNA). In all nodules of procarcinogen-induced murine hepatocellular carcinomas (HCCs) and human HCCs, expression was markedly elevated compared to the uninvolved liver. Quantitative analyses indicated a 6-7-fold increased RNA level in HCCs versus uninvolved liver, advancing this as a molecule of interest. This ncRNA was overexpressed in all five non-hepatic human carcinomas analysed, consistent with a potential marker for neoplastic cells and potential participant in the molecular cell biology of neoplasia.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Biomarkers
  • Biomarkers, Tumor / genetics*
  • Carcinoma, Hepatocellular / genetics*
  • Carcinoma, Hepatocellular / metabolism
  • Carcinoma, Hepatocellular / pathology
  • Cell Line, Tumor
  • Conserved Sequence
  • Humans
  • Mice
  • Molecular Sequence Data
  • Neoplasms / genetics*
  • Neoplasms / metabolism
  • Neoplasms / pathology
  • Phylogeny
  • Proteins / chemistry
  • Proteins / genetics
  • Proteins / metabolism
  • RNA, Untranslated / genetics*
  • RNA, Untranslated / metabolism
  • Sequence Alignment
  • Transcription, Genetic / genetics


  • Biomarkers
  • Biomarkers, Tumor
  • Proteins
  • RNA, Untranslated

Associated data

  • GENBANK/AY722410