[Comparative evaluation of the neuroprotective activity of phenibut and piracetam under experimental cerebral ischemia conditions in rats]

Eksp Klin Farmakol. May-Jun 2006;69(3):19-22.
[Article in Russian]

Abstract

The neuroprotective properties of phenibut and piracetam were studied in rats with cerebral ischemia caused by bilateral irreversible simultaneous occlusion of carotid arteries and gravitational overload in craniocaudal vector. In addition, the effects of both drugs on microcirculation in brain cortex under ischemic injury conditions were studied. Phenibut and (to a lower extent) piracetam reduced a neuralgic deficiency, amnesia, and the degree of cerebral circulation drop, and improved the spontaneous movement and research activity deteriorated by brain ischemia.

Publication types

  • Comparative Study

MeSH terms

  • Animals
  • Anticonvulsants / administration & dosage*
  • Brain Ischemia / drug therapy*
  • Cerebral Cortex / blood supply
  • Cerebrovascular Circulation / drug effects
  • Disease Models, Animal
  • Drug Evaluation, Preclinical
  • Male
  • Neuroprotective Agents / administration & dosage*
  • Piracetam
  • Rats
  • Rats, Wistar
  • gamma-Aminobutyric Acid / administration & dosage
  • gamma-Aminobutyric Acid / analogs & derivatives*

Substances

  • Anticonvulsants
  • Neuroprotective Agents
  • gamma-Aminobutyric Acid
  • 4-amino-3-phenylbutyric acid
  • Piracetam