The effect of whole organ pancreas transplantation and PIT on diabetic complications

Curr Diab Rep. 2006 Aug;6(4):323-7. doi: 10.1007/s11892-006-0068-x.


Diabetes mellitus is a leading cause of morbidity and mortality in the Western world. Currently, the only forms of beta-cell replacement are whole organ pancreas transplantation and pancreatic islet transplantation. Whole organ transplantation has demonstrated benefits in prevention and reversal of diabetic complications with sustainable long-term outcomes. Pancreatic islet transplantation continues to be a field that needs further study to ascertain the true benefit of islet transplantation for diabetic complications. This can only be achieved with improvement in long-term islet allograft survival.

Publication types

  • Review

MeSH terms

  • Diabetes Complications / physiopathology
  • Diabetes Complications / surgery*
  • Diabetes Mellitus, Type 1 / surgery*
  • Diabetic Angiopathies / physiopathology
  • Diabetic Nephropathies / physiopathology
  • Diabetic Neuropathies / physiopathology
  • Diabetic Retinopathy / physiopathology
  • Humans
  • Islets of Langerhans Transplantation / methods*
  • Pancreas Transplantation / methods*
  • Treatment Outcome