B-1 B cells: development, selection, natural autoantibody and leukemia

Curr Opin Immunol. 2006 Oct;18(5):547-55. doi: 10.1016/j.coi.2006.07.010. Epub 2006 Aug 1.


B-1 (CD5+) B cells constitute a phenotypic and functionally distinct population of B cells in mouse that show enriched expression of autoreactive B-cell antigen receptors and that produce several types of natural autoantibodies. Recently, there has been much progress in this field of research. Evidence has appeared for the existence of distinctive B-cell precursors that preferentially generate B-1 B cells, and the crucial requirement for strong B-cell antigen receptor signaling in the maturation of B-1 B cells has been established. Other work focuses on a phenotypically similar population that lacks CD5, termed 'B-1b', which shows similarities and differences from most CD5+ B cells in both development and function. The relationship of normal B-1 cells with B-cell lymphomas and leukemias continues to be a subject of interest and debate.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Autoantibodies / blood
  • Autoantigens / immunology
  • B-Lymphocyte Subsets / immunology
  • B-Lymphocyte Subsets / physiology*
  • CD5 Antigens
  • Immunophenotyping
  • Leukemia / blood
  • Leukemia / immunology*
  • Lymphopoiesis
  • Mice
  • Receptors, Antigen, B-Cell / immunology
  • Signal Transduction


  • Autoantibodies
  • Autoantigens
  • CD5 Antigens
  • Receptors, Antigen, B-Cell