The Inhibitory Effects of Eckol and Dieckol From Ecklonia Stolonifera on the Expression of Matrix metalloproteinase-1 in Human Dermal Fibroblasts

Biol Pharm Bull. 2006 Aug;29(8):1735-9. doi: 10.1248/bpb.29.1735.


In order to develop new anti-photoaging agents, we examined the inhibitory effects of 29 seaweed extracts on transcriptional activities of NF-kappaB and AP-1, and MMP-1 expression. The extracts from 3 species of Alariaceae, Eisenia bicyclis, Ecklonia cava and Ecklonia stolonifera, have showed strong inhibition of both NF-kappaB and AP-1 reporter activity, which were well correlated with their abilities to inhibit MMP-1 expression. In addition, MMP-1 expression was dramatically attenuated by treatment with eckol or dieckol which were purely isolated from E. stolonifera, indicating that these compounds are active principles to inhibit MMP-1 expression in human dermal fibroblasts. Taken together, our data demonstrate the inhibitory effect of eckol and dieckol from Ecklonia species on MMP-1 expression in human dermal fibroblasts and provide a possibility to develop as an agent for the prevention and treatment of skin aging.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Base Sequence
  • Benzofurans / pharmacology*
  • Blotting, Western
  • Cells, Cultured
  • DNA Primers
  • Dioxins / pharmacology*
  • Fibroblasts / drug effects
  • Fibroblasts / enzymology
  • Humans
  • Matrix Metalloproteinase 1 / genetics
  • Matrix Metalloproteinase 1 / metabolism*
  • Phaeophyta / chemistry*
  • Reverse Transcriptase Polymerase Chain Reaction
  • Skin / cytology
  • Skin / drug effects*
  • Skin / enzymology


  • Benzofurans
  • DNA Primers
  • Dioxins
  • dieckol
  • eckol
  • Matrix Metalloproteinase 1