A cytotoxic saponin from Albizia julibrissin

Chem Pharm Bull (Tokyo). 2006 Aug;54(8):1211-2. doi: 10.1248/cpb.54.1211.

Abstract

A new triterpenoidal saponin (1: Julibroside J(21)) with a xylopyranosyl moiety located at its C-21 side chain was isolated from Albizia julibrissin DURAZZ. (Leguminosae), and its structure was determined on the basis of comprehensive spectroscopic analyses. Compound 1 showed marked inhibitory action against Bel-7402 cancer cell line at 10 microg/ml.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Albizzia / chemistry*
  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / pharmacology
  • Cell Line, Tumor
  • Cell Proliferation / drug effects*
  • Drug Screening Assays, Antitumor
  • Hepatocytes / drug effects
  • Humans
  • Molecular Structure
  • Saponins / chemistry*
  • Saponins / pharmacology*

Substances

  • Antineoplastic Agents
  • Saponins
  • julibroside J(21)